Effect of disruption of IL-6 in cachectic C26 tumor on gene expression

ABSTRACT: The IL-6 was reported as a key cachectic factor in mice inoculated with colon carcinoma 26 (C26) cells, a widely used cancer cachexia model. However, we identified We found that the growth of IL-6 KO tumors was dramatically delayed. More strikingly, while IL-6 KO tumors eventually reached the similar size as wild-type tumors, cachexia still took place, despite no elevation in circulating IL-6. We further showed that IL-6 promotes tumor growth by facilitating immune evatioon but is dispensable for cachexia.

ORGANISM(S): Mus musculus

PROVIDER: GSE253861 | GEO | 2024/04/10

REPOSITORIES: GEO