Single-cell transcriptome analysis reveals effector CD8+ T cells may play an important role in residual chronic immune activation and inflammation in HIV-1 infected patients

ABSTRACT: Despite antiretroviral therapy (ART) suppressed viremia and reduced mortality in HIV-1 infected patients, residual chronic immune activation and inflammation in these patients can lead to an increased risk of non-communicable diseases, while the mechanism is still not clear. Harnessing scRNA-seq of PBMC of HIV-1 patients receiving ART and public avaialable scRNA-seq data, we found that the proportion of CD4+ T cells, CD8+ T cells, monocytes, and B cells showed variation in these patients. Through cluster analysis, it was found that effector CD8+ T cells were significantly decreased in HIV infected patients and lsATR, but increased in fsART, migration inhibitory factor (MIF) signaling was significantly increased in fsART.

ORGANISM(S): Homo sapiens

PROVIDER: GSE254301 | GEO | 2024/01/31

REPOSITORIES: GEO