A low-abundance class of Dicer-dependent siRNAs produced from a variety of features in C. elegans
Ontology highlight
ABSTRACT: Canonical small interfering RNAs (siRNAs) are generated by the cleavage of double-stranded RNA (dsRNA) by the ribonuclease Dicer. siRNAs are found in plants, animals, and some fungi where they bind to Argonautes to direct RNA silencing. In this study, we characterized the canonical Dicer-dependent siRNAs of C. elegans. We identified thousands of endogenous loci, representing dozens of unique elements, that give rise to low to moderate levels of siRNAs, called 23H-RNAs. These loci include repetitive elements, alleged coding genes, pseudogenes, non-coding RNAs, and unannotated features, many of which adopt hairpin structures.
ORGANISM(S): Caenorhabditis elegans
PROVIDER: GSE254442 | GEO | 2024/01/29
REPOSITORIES: GEO
ACCESS DATA