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Identification of calcineurin-dependent gene expression changes in response to chronic CaCl2 stress

ABSTRACT: Gene expression was quantified in S. cerevisae cells over a time course of three days of CaCl2 treatment to activate calcineurin. Wild type (WT) and cnb1 mutant strains were compared to allow the identification of calcineurin-dependent gene expression changes. We show that mitochondrial genes are downregulated, and ribosome biogenesis genes are upregulated, in both geneotypes over time.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE254551 | GEO | 2024/03/19

REPOSITORIES: GEO

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Identification of calcineurin-dependent, Crz1-independent gene expression changes in response to chronic CaCl2 stress

Project description:Gene expression was quantified in S. cerevisae cells over a time course of three days of CaCl2 treatment to activate calcineurin. crz1 and crz1 cnb1 mutant strains were compared to allow the identification of calcineurin-dependent gene expression changes that are independent of the downstream transcription factor Crz1. We show that mitochondrial genes are downregulated in both geneotypes over time. Additionally, genes that promote glutathione biosynthesis are upregulated in cells that express calcineurin.

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