Splicing targeting approaches highlight actionable vulnerabilities in triple negative breast cancer

ABSTRACT: To investigate if pharmacological inhibition of splicing could uncover novel actionable vulnerabilities in TNBC, we profiled the genome-wide transcriptional changes elicited in MDA-MB-231 cells by treatment with Indisulam, that promote degradation of the splicing, and Pladienolide B, that impairs the activity of SF3B1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE254842 | GEO | 2025/03/11

REPOSITORIES: GEO