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ADCY1-mediated cAMP signaling pathway mediates the neuropsychiatric effects of montelukast

ABSTRACT: Human forebrain organoids (day 100) derived from U2F iPS cell line were exposed with or without 20 ng/ml and 400 ng/ml montelukast (MTK) for 7 days. Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that MTK exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse. These downregulated genes were also significantly overlapped with genes reported to be associated with schizophrenia, bipolar disorder, and autism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255033 | GEO | 2025/06/16

REPOSITORIES: GEO

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