Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [BulkRNA]

ABSTRACT: Through a multi-omics approach, we discovered that metformin acts by enhancing the methylation potential in Dnmt3aR878H/+ cells and reversing their aberrant DNA CpG methylation and histone H3K27 trimethylation (H3K27me3) profiles.

ORGANISM(S): Mus musculus

PROVIDER: GSE255100 | GEO | 2025/02/07

REPOSITORIES: GEO