Characterization of cuprizone mouse model at single-cell and spatial transcriptomics level[Spatial Transcriptomics]

ABSTRACT: We generated a comprehensive dataset utilizing the cuprizone model. This dataset encompasses bulk RNA-seq, single-nucleus RNA-seq (snRNA-seq), and spatial transcriptomics, with the aim of investigating the molecular changes linked to the cuprizone-induced demyelination phenotype. Integration of these omics dataset allowed us to investigate the changes occurring at both the single-cell and spatial levels, thereby enabling a deeper understanding of the cellular dynamics and molecular interactions associated with the cuprizone-induced demyelination phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE255370 | GEO | 2024/11/06

REPOSITORIES: GEO