Acute atopic dermatitis and urticaria imprints peripheral monocytes with proinflammatory-prone signature

ABSTRACT: Monocytes from patients with type 2 immune disorders exhibited an augmented inflammatory response upon LPS stimulation. RNA-seq analysis demonstrated significant upregulation of inflammatory cytokines, including IL-6, IL-12, and IL-1b. Moreover, there was a conspicuous enrichment of signaling pathways associated with inflammation. ATAC sequencing revealed heightened chromatin accessibility in patient monocytes, particularly in the promoter regions of inflammatory genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255396 | GEO | 2024/02/28

REPOSITORIES: GEO