Paired CRISPR screens to map gene regulation in cis and trans (HiChIP)

ABSTRACT: In this study, we develop a scalable approach that pairs discovery of cis- and trans-acting elements to systematically decipher the gene regulatory network. We explore the regulation of the immune checkpoint PD-L1 under both basal and IFNγ-stimulated contexts. PD-L1 expression on tumor cells serves as a clinically-actionable diagnostic for immune checkpoint blockade therapy across multiple cancer types.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255700 | GEO | 2024/11/28

REPOSITORIES: GEO