FGF4 stimulation increases variability in mESCs [scRNA-seq]

ABSTRACT: FGF4 is essential for Epiblast and Primitive Endoderm formation in the mouse embryo and promotes differentiation of mouse embryonic stem cells. However, different FGF-concentrations regulate gene expression quantitatively remained an open question. We used single-cell RNA sequencing to quantify transcriptional variability and dynamics upon FGF4 stimulation of Fgf4-mutant mESCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE256059 | GEO | 2025/02/26

REPOSITORIES: GEO