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Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNA molecules which function as negative gene regulators. The tissue expression profile of miRNAs shows great promise as a novel biomarker for diagnosis of cancer and other diseases. In addition, some recent reports have demonstrated that are present in human serum and plasma which could make them an ideal non-invasive biomarker for diagnosis of cancer. The aim of this study is to analyze the value/efficacy of the expression profile of plasma miRNAs in differentiating between patients with advanced adenomas and CRC and healthy individuals.

ORGANISM(S): Homo sapiens

PROVIDER: GSE25609 | GEO | 2013/01/11

SECONDARY ACCESSION(S): PRJNA134259

REPOSITORIES: GEO

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Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening

Project description:MicroRNAs (miRNAs) are small non-coding RNA molecules which function as negative gene regulators. The tissue expression profile of miRNAs shows great promise as a novel biomarker for diagnosis of cancer and other diseases. In addition, some recent reports have demonstrated that are present in human serum and plasma which could make them an ideal non-invasive biomarker for diagnosis of cancer. The aim of this study is to analyze the value/efficacy of the expression profile of plasma miRNAs in differentiating between patients with advanced adenomas and CRC and healthy individuals. The microRNA profiling study comprises serum plasmas from 20 Control, 21 colorectal cancer,20 advanced adenomas.The study also include some samples from patients after treatment.

2013-01-11 | E-GEOD-25609 | biostudies-arrayexpress

MicroRNAs as potential biomarkers for APE

Project description:Acute pulmonary embolism (APE) remains among the most formidable challenges facing public health practice in the 21st century. Accurate diagnosis of APE is severely hindered by the lack of biomarkers with both high sensitivity and specificity. MicroRNAs (miRNAs) involve various pathophysiologic processes underlying multitudinous diseases. Accmulating evidences point to the fact that miRNAs may serve as ideal biomarkers.The aim of the present study was to explore the potential of plasma miRNAs as biomarkers for diagnosis of APE. Two TaqMan miRNA arrays were performed on plasma of 10 APE patients and 10 healthy controls.

2013-08-08 | E-GEOD-24149 | biostudies-arrayexpress

Plasma circulating MiRNAs: a new potential biomarker for prostate cancer diagnosis.

Project description:Plasma circulating MiRNAs: a new potential biomarker for prostate cancer diagnosis.

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MicroRNAs as potential biomarkers for APE

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Analysis of circulating microRNAs in adrenocortical tumours

Project description:Differential diagnosis of adrenocortical adenoma and carcinoma is of pivotal clinical relevance, as the prognosis and clinical management of benign and malignant adrenocortical tumours is entirely different. Circulating microRNAs are promising biomarker candidates of malignancy in several tumours. In the present study we investigate circulating microRNAs in adrenocortical tumours and to evaluate their potential applicability as biomarkers of malignancy. For the miRNA profiling, 8 preoperative plasma samples obtained from patients with adrenocortical adenomas and carcinomas and were studied by microarray.

2013-11-19 | E-GEOD-49674 | biostudies-arrayexpress

Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease

Project description:Our study provides a valuable resource for small RNA profiles in normal, iRBD and PD plasma EVs, and showed that the EV-miRNAs have the potential to serve as biomarker for diagnosing the PD patients and iRBD patients.

2024-01-16 | GSE166070 | GEO

A landscape of circular RNAs expression in the castration-resistant prostate cancer

Project description:Prostate cancer is one of the major cancers that seriously affect men's health. It has high morbidity and high mortality, but there is still no ideal molecular markers for the diagnosis and prognosis of prostate cancer. Castration-resistant prostate cancer is associated with wide variations in survival. To determine whether differentially expressed circRNAs in plasma exosomes can be used as a novel biomarker for castration-resistant prostate cancer prognosis, we performed high-throughput circRNA sequencing on 15 pairs of plasma exosomes from 30 metastatic castration-resistant prostate cancer patients, with or without early progression, to screen differentially expressed circRNAs.

2023-04-05 | GSE125256 | GEO

MicroRNA profiling of benign and malignant adrenocortical tumors reveals potential biomarkers of recurrence

Project description:MicroRNAs are small, non-coding RNAs that regulate gene expression at post-transcriptional levels. There is increasing evidence to suggest that miRNAs could be useful in cancer diagnosis, prognosis, and therapy. The aim of our study was to identify miRNAs predictors of poor prognosis in adrenocortical cancer. miRNA microarray expression profiling was performed on a cohort of 6 adenomas, 6 non-recurrent carcinomas (Carc_B) and 6 recurrent carcinomas (Carc_A). We identified several miRNAs that were differentially expressed between adenomas and carcinomas as well as between Carc_A and Carc_B. We found that the best discriminatory miRNAs between carcinomas and adenomas were miR-195 and miR-335 which were down-regulated in carcinomas. MiR-139-5p was the most powerful discriminatory miRNA between Carc_A and Carc_B subtypes with consistent up-regulation in the recurrent carcinoma subgroup (Carc_A). Target prediction analysis showed that predicted targets of these miRNAs could be involved in biological processes and pathways that enhance tumor progression. Our data suggest that adrenocortical cancer cells progressively switch from a high miR-195 and miR-335 status to a low miR-195 and miR-335 phenotype. MiR-139-5P is a potential prognostic biomarker of recurrent adrenocortical carcinomas.

2013-06-30 | GSE43279 | GEO

A machine learning breast cancer prediction model based on a panel from circulating exosomal miRNAs

Project description:In this study, we aim to reveal the value of plasma exo-miRNA in early diagnosis of breast cancer.In this study, after determining the success of plasma exocrine separation, we analyzed the expression of miRNA in plasma exocrine and selected 16 strong correlation features miRNA by Lasso logistic regression. Different machine learning algorithm models were constructed to evaluate the performance of 16 miRNA for early detection and diagnosis of breast cancer. The biological significance of 16 characteristic miRNAs was evaluated by bioinformatics analysis. Overall, these data highlight the value of exo-miRNA as a biomarker for breast cancer. They may be used for early detection and diagnosis of breast cancer in future clinical practice.

2022-02-21 | GSE197020 | GEO

MicroRNA profiling of benign and malignant adrenocortical tumors reveals potential biomarkers of recurrence

2013-06-30 | E-GEOD-43279 | biostudies-arrayexpress

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