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Neutral sphingomyelinase 2 inhibition alters inflammatory gene expression signatures in the brain of mice infected with West Nile virus

ABSTRACT: To investigate the in vivo effects of DPTIP during WNV infection in a mouse model, we compared infected mice with WNV NY99 treated with DPTIP or vehicle and uninfected (mock) mice. DPTIP is a pro-dug that targets mouse nSMASE. We then performed gene expression profiling analysis using data obtained from RNA-seq from infected-vehicle mice, uninfected mice and infected DPTIP-treated mice

ORGANISM(S): Mus musculus

PROVIDER: GSE256333 | GEO | 2025/07/16

REPOSITORIES: GEO

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