Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain

ABSTRACT: To understand the common and opposite effects of mitochondrial and lysosomal perturbations on cellular signaling, we performed RNAseq in HeLa cells stably silenced for the mitochondrial respiratory chain subunit UQCRC1 (as a model of chronic mitochondrial respiratory chain deficiency), for lysosomal hydrolase acid alpla-glucosidase (GAA), or for lysosomal cathepsin B (CTSB). The controls were HeLa cells with scrambled shRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE256471 | GEO | 2024/05/24

REPOSITORIES: GEO