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PLA2G4E Orchestrates optimal Synapse Development and Neuronal Maturation [shPLA2G4E]

ABSTRACT: Constitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity markers compared to wild-type counterparts.We performed gene expression profiling analysis os neurons lacking PLA2G4E to study the function of this enzyme in synaptic transmission.

ORGANISM(S): Mus musculus

PROVIDER: GSE259324 | GEO | 2025/07/08

REPOSITORIES: GEO

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PLA2G4E Orchestrates optimal Synapse Development and Neuronal Maturation [KO_Pla2g4e]

Project description:Constitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity markers compared to wild-type counterparts.We performed gene expression profiling analysis animals lacking PLA2G4E to study the function of this enzyme in memory function.

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