Genomics

Dataset Information

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Gene expression in mouse liver depleted of HDAC3


ABSTRACT: Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of the HDAC3 gene encoding the catalytic domain of HDAC3) one week after the injection of AAV2/8-Tbg-Cre virus. Livers from the HDAC3 fl/fl mice injected with AAV2/8-Tbg-GFP were used as normal controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE25937 | GEO | 2011/03/11

SECONDARY ACCESSION(S): PRJNA135689

REPOSITORIES: GEO

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