The effect of high fat diet on mouse prostate development

ABSTRACT: Steroid 5α reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development and growth. Despite the introduction of steroid 5α-reductase inhibitors (5ARI) for benign prostatic hyperplasia (BPH), the progression of LUTS is only slowed by 34% with 5ARI-response. Previous literature establishes link between obesity and BPH progression. We hypothesize that high fat diet is associated with prostate development.

ORGANISM(S): Mus musculus

PROVIDER: GSE260450 | GEO | 2024/03/03

REPOSITORIES: GEO