T-bet deficiency and Hic1 induction override TGF-b-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

ABSTRACT: TGF-beta signaling is required for the differentiation of gut-resident memory CD8 T cells. Here, we showed that the deficiency of transcription factor T-bet partially rescued the differentiation of TGF-beta receptor deficient gut-resident memory CD8 T cells. Hic1 induction further strengthens TRM maturation in the absence of TGF-b and T-bet.

ORGANISM(S): Mus musculus

PROVIDER: GSE260630 | GEO | 2024/03/10

REPOSITORIES: GEO