ATAC-seq Profiling of Mixed Stage C. elegans Neuronal Nuclei

ABSTRACT: Using ATAC-seq, we aimed to identify regions of open chromatin in the developing C. elegans nervous system. This dataset was used to determine regions of chromatin and compare it to ChIP-seq data of TFs of interest, to assist us in identifying ChIP-seq peaks which are solely expressed in neurons (vs. general, total worm binding). Specifically, since EGL-43 is expressed in many tissues, including both neuronal and the somatic gonad, ATAC-seq was particularly helpful in identifying neuronal-specific ChIP-seq peaks and NanoDam peaks of interest (GSE227552).

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE260636 | GEO | 2024/05/29

REPOSITORIES: GEO