Transcriptomics

Dataset Information

0

Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes

ABSTRACT: To investigate the effect of glucose hypometabolism on the transcriptome of human neurons

ORGANISM(S): Homo sapiens

PROVIDER: GSE260665 | GEO | 2024/03/06

REPOSITORIES: GEO

Json Xml

Similar Datasets

Unknown Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes
| S-SCDT-10_1038-S44319-024-00140-7 | biostudies-other
Unknown Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
| S-EPMC7391607 | biostudies-literature
Unknown Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
| S-EPMC7384305 | biostudies-literature
Unknown Metformin inhibits RAN translation through PKR pathway and mitigates disease in <i>C9orf72</i> ALS/FTD mice.
| S-EPMC7414156 | biostudies-literature
Unknown Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD.
| S-EPMC8616043 | biostudies-literature
Unknown A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
| S-EPMC8519953 | biostudies-literature
Unknown RNA-mediated toxicity in C9orf72 ALS and FTD.
| S-EPMC7572710 | biostudies-literature
Unknown Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD.
| S-EPMC5997509 | biostudies-literature
Unknown C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies.
| S-EPMC6546170 | biostudies-literature
Unknown Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
| S-EPMC4632245 | biostudies-literature