Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

ABSTRACT: Comparison of gene expression profiles of disseminated cancer cells with primary tumors and metastatic tumors

ORGANISM(S): Mus musculus

PROVIDER: GSE261236 | GEO | 2025/02/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

Project description:Comparison of gene expression profiles of disseminated cancer cells with primary tumors and metastatic tumors

2025-02-11 | GSE261959 | GEO

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells II

Project description:Comparison of gene expression profiles of disseminated cancer cells with primary tumors and metastatic tumors

2025-02-12 | GSE261237 | GEO

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

Project description:Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

| PRJNA1089633 | ENA

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

Project description:Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells

| PRJNA1086141 | ENA

Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells II

Project description:Anti-tumor CD4Th1 cells controls the migration and outgrowth of disseminated cancer cells II

| PRJNA1086143 | ENA

Genomic alterations indicate tumor origin and varied metastatic potential of disseminated cells from prostate cancer

Project description:Disseminated epithelial cells can be isolated from the bone marrow of a far greater frac-tion of prostate-cancer patients than the fraction of patients who progress to metastatic disease. To provide a better understanding of these cells, we have characterized their genomic altera-tions. We first present an array comparative genomic hybridization method capable of detecting genomic changes in the small number of disseminated cells (10-20) that can typically be ob-tained from bone-marrow aspirates of prostate-cancer patients. We show multiple regions of copy-number change, including alterations common in prostate cancer, such as 8p loss, 8q gain, and gain encompassing the androgen-receptor gene on Xq, in the disseminated cell pools from 11 metastatic patients. We found fewer and less striking genomic alterations in the 48 pools of disseminated cells from patients with organ-confined disease. However, we identify changes shared by these samples with their corresponding primary tumors and prostate-cancer altera-tions reported in the literature, evidence that these cells, like those in advanced disease, are disseminated tumor cells (DTCs). We also demonstrate that DTCs from patients with advanced and localized disease share several abnormalities, including losses containing cell-adhesion genes and alterations reported to associate with progressive disease. These shared alterations might confer the capability to disseminate or establish secondary disease. Overall, the spectrum of genomic deviations is evidence for metastatic capacity in advanced-disease DTCs and varia-tion in that capacity in DTCs from localized disease. Our analysis lays the foundation for eluci-dation of the relationship between DTC genomic alterations and progressive prostate cancer. Keywords: array comparative genomic hybridization, prostate cancer, disseminated cells

2008-08-17 | GSE11155 | GEO

Gene expression of disseminated neuroblastoma

Project description:Comprehensive expression profiling of disseminated neuroblastoma with favorable and unfavorable outcome using SAGE. Results provide insight into the molecular pathogenesis of spontaneous regression and progression of metastatic neuroblastoma and may be used for improving risk estimation of patients with disseminated neuroblastoma. Keywords: gene expression SAGE-based, neuroblastoma, primary tumor, disseminated disease Samples analyzed: 9 (stage 4S neuroblastoma: n=5, stage 4 neuroblastoma: n=3, neuroblastoma cell line: n=1)

2006-09-06 | E-GEOD-4991 | biostudies-arrayexpress

Gene expression of disseminated neuroblastoma

2006-09-06 | GSE4991 | GEO

Comparison of expression profiles of breast tumors with or without presence of disseminated tumor cells

Project description:We used here the presence of disseminated tumors cells (DTC) in the bone marrow for defining early metastasized breast cancer patients. By comparing expression profiles of early metastasized primary breast tumors with non-metastasized tumors, we found candidate metastasis suppressor genes that were further validated in other published breast cancer data.

2015-04-01 | E-MTAB-2501 | biostudies-arrayexpress

Investigating the contribution of early and late disseminated tumor cells in lung metastasis progression

Project description:Recent pioneering work in the field has not only described the presence of early neoplasm-derived cancer cells in the metastatic niche but has elucidated several underlying mechanisms responsible for their seeding. Yet, it remains unclear how early cancer cells interact with their new cellular environment once disseminated. In the present work, we aimed to address the knowledge gap related to how the immune microenvironment responds to and influences the fate of early compared to later arriving disseminated tumor cell (DTC) seeds. To distinguish early vs. late seeding cancer cells, we first engineered barcoded cancer cell lines and then conducted multiple, staggered injections in a triple negative breast cancer (TNBC) lung metastasis context. Our preliminary data showed that early timepoint injected cancer cells preferentially proliferate despite not harboring genetic and transcriptomic advantages compared to later arriving cancer cells. Furthermore, single cell RNA-seq analysis of barcoded cancer cells extracted from lung metastases and immune cells revealed an anti-inflammatory tumor associated macrophage (TAM) cluster expressing high triggering receptor expressed on macrophages 2 (Trem2) program genes and complement component q (C1q).

2026-07-04 | GSE309120 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data