Genome-wide studies identify the role of PML/RARα phase separation in PML/RARα-driven transcriptional dysregulation.

ABSTRACT: Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosome translocation that generates the promyelocytic leukemia/retinoic acid receptor-α (PML/RARα) fusion gene. However, the mechanism underlying PML/RARα mediated transcriptional dysregulation remain unclear. Here, we performed the transcription profiling in NB4, an APL patient-derived cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261293 | GEO | 2024/12/31

REPOSITORIES: GEO