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Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

ABSTRACT: In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compared to human lung tissue-derived fibroblasts. To find the responsible genes for this phenomena, we used microarray analysis to find the expression difference between lung tissue-derived fibroblasts and vascular adventitial fibroblas

ORGANISM(S): Homo sapiens

PROVIDER: GSE26146 | GEO | 2010/12/18

SECONDARY ACCESSION(S): PRJNA135299

REPOSITORIES: GEO

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Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

Project description:In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compared to human lung tissue-derived fibroblasts. To find the responsible genes for this phenomena, we used microarray analysis to find the expression difference between lung tissue-derived fibroblasts and vascular adventitial fibroblas Cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts were analyzed in replicates.

2010-12-18 | E-GEOD-26146 | biostudies-arrayexpress

Targeted RNA sequencing of varicella zoster virus-infected human brain vascular adventitial fibroblasts

Project description:Transcriptome analysis of VZV infected primary human brain vascular adventitial fibroblasts (HBVAFs)

2021-11-17 | GSE175797 | GEO

Homo sapiens

Project description:Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

| PRJNA135299 | ENA

Targeted RNA sequencing of varicella zoster virus-infected human brain vascular adventitial fibroblasts

Project description:Targeted RNA sequencing of varicella zoster virus-infected human brain vascular adventitial fibroblasts

| PRJNA733761 | ENA

P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

Project description:We report differentially expressed genes in human pulmonary arterial adventitial fibroblasts under genotoxic stress (Doxorubicin) or pharmacological p53-activation by Nutlin-3.

2021-03-03 | GSE154101 | GEO

P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

Project description:P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

| PRJNA645130 | ENA

TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma

Project description:Invasive lung adenocarcinoma (LADC) is classified histologically as lepidic, acinar, papillary, micropapillary, or solid. We found that A549 human LADC cells formed tumors with distinct histological features—solid-type or acinar-type tumors—depending on the site of development in immunodeficient mice and that a solid-to-acinar transition (SAT) could be induced by cancer-associated fibroblasts (CAFs) in 3D cocultures with A549. To clarify the molecular mechanisms contributing to SAT induction, we performed RNA-seq analysis of four A549 tumor cell samples derived from solid- or acinar-type tumor tissue formed in vivo or from 3D tumor colonies formed in the presence or absence of CAFs in vitro.

2022-03-15 | GSE169029 | GEO

EPIC methylation array of human lung fibroblasts

Project description:EPIC Array data from human lung fibroblasts isolated from fresh and cryopreserved lung tissue (16 samples, 3 donors)

| EGAD00010002463 | EGA

Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [pul28]

Project description:Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that culminates in right heart failure. Vascular pathology in PH is characterized by pulmonary vasoconstriction and progressive vascular remodeling processes that affects all layers of the vascular wall (intima, media and adventitia). Our objective was to profile and analyze the differential gene expression signatures between the cells isolated from normal and idiopathic PAH patients. We generated vascular cell-specific transcriptome profiles from the adventitial fibroblasts (PAAF) isolated ex vivo from the dissected human pulmonary arteries of normal donor and PAH lungs using paired-end RNA-sequencing.

2022-06-09 | GSE193776 | GEO

Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [ChIP-seq]

2022-06-09 | GSE144935 | GEO

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