Alternative splicing events driven by altered levels of Gemin5 undergo translation

ABSTRACT: We show that upregulation of Gemin5 can be detrimental as it modifies the steady state of mRNAs and enhances alternative splicing (AS) events of genes involved in a broad range of cellular processes. RNA-Seq analyses of the mRNA associated with polysomes in cells with high levels of Gemin5 revealed that a significant fraction of the differential AS events was enriched in polysomes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261488 | GEO | 2024/08/19

REPOSITORIES: GEO