Pim1 exacerbates inflammatory arthritis by mediating Th17 differentiation

ABSTRACT: The present study demonstrated that pim1-promoted mito-Ca2+ influx enhanced the activity of mitochondrial OXPHOS, bringing about the differentiation of Th17 and driving the pathogenic progression of inflammatory arthritis. Targeting pim1 impeded Th17 differentiation and alleviated collagen-induced arthritis (CIA) and SKG arthritis, suggesting that Pim1 is a target for the treatment of inflammatory arthritis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261671 | GEO | 2026/03/04

REPOSITORIES: GEO