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Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells in response to in situ Flt3L expresson

ABSTRACT: In Panc02 tumor, in situ Flt3L expression promotes expansion of asGM1-expressing CD8+ T cells. Our RNA-sequencing analysis has revealed transcriptionally distinct populations of CD8+ T cells based on expression of asGM1.

ORGANISM(S): Mus musculus

PROVIDER: GSE261675 | GEO | 2025/03/15

REPOSITORIES: GEO

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Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells in response to in situ Flt3L expresson

Project description:Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells in response to in situ Flt3L expresson

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Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells in response to PD-1 inhibition

Project description:In Panc02 tumor, PD-1 blockade promotes expansion of asGM1-expressing CD8+ T cells. Our RNA-sequencing analysis has revealed transcriptionally distinct populations of CD8+ T cells based on expression of asGM1.

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Project description:We found that ASGM1-positive CD8 T cells are the predominant intrahepatic ASGM1-positive immune cells in NFIL3 KO mice. Our goal is using transcriptome analysis to reveal ASGM1-positive CD8 T cells had distinct gene profiles from ASGM1-negative ones.

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Identification of a glycosphingolipid+ immune regulatory innate-like CD8 T-cell network in old mice

Project description:The reciprocal decline in naive (TN) and increase in virtual (TVM) and true memory (TTM) CD8 T-cell frequencies upon aging is incompletely understood. We established the glycosphingolipid asialo-GM1 (AsGM1) marker present on >70% of TVM/TTM and 5-15% TN to target their immune-regulatory and homeostatic potential. We identified a novel AsGM1+ old CD8 TN-subset that was related to antigen-experienced AsGM1+ CD8 TTM and showed an initial immune-regulatory (Pdcd1, Il10) gene expression signature. The program for AsGM1+ CD8 T-subsets was imprinted genetically in young and old hematopoietic stem cells that reconstitute young and old donor-type immune systems in lymphophenic RAG1-/- mice within 16 weeks, respectively. However, antibody-mediated depletion of AsGM1+ T cells in old mice revealed a disturbed recovery of CD8 TVM resulting in a rejuvenated T-subset composition and T-cell priming capacity upon DNA-vaccination. Old CD8 TVM and IL10+ PD-1+ TTM exerted immune-regulatory functions and suppressed CD3/CD28-mediated activation of TN in vitro. Glycosphingolipids thus are attractive to identify and target novel T-subsets.

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Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells from mouse pancreatic tumor

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Splenic CD8+ and CD8- DCs

Project description:Analysis of gene expressions in mouse splenic dendritic cells (DCs). DCs were purified into two subsets, CD8-positive and -negative ones. DCs were expanded in vivo by injecting Flt3L-producing tumors into the backs of C57BL/6 mice. To expand DCs in vivo, Flt3L-producing B16 melanoma cells were injected to the backs of mice. Then, 10-12 days later, splenic DCs were enriched by MACS and purified into CD3-B220-CD8a+CD11c+ and CD3-B220-CD8a-CD11c+ cells by FACS cell sorter.

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Gene expression profiles of intratumoral asGM1- and asGM1+CD8+ T cells in response to PD-1 inhibition

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Flt3L in Treating Patients With Metastatic Colorectal Cancer

Project description:RATIONALE: Flt3L may stimulate a person’s immune system and help kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of flt3L given to patients before undergoing surgery to remove metastases from colorectal cancer.

| 2002961 | ecrin-mdr-crc

Flt3l

Project description:Mus musculus Flt3l, FMS-like tyrosine kinase 3 ligand [Source:MGI Symbol;Acc:MGI:95560], is differentially expressed in 36 experiment(s);

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