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Jurkat CRISPRi ATAC-seq [Series 3]

ABSTRACT: We develop a system for bidirectional epigenetic editing (CRISPRai), in which orthogonal activating (CRISPRa) and repressive (CRISPRi) perturbations are applied simultaneously to multiple loci the same cell. We perform ATAC-seq on CRISPRi perturbed Jurkat T cells to investigate chromatin accessibility changes upon perturbation of individual regulatory elements.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261695 | GEO | 2024/03/16

REPOSITORIES: GEO

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