Enterovirus-A71 Preferentially Infects and Replicates in Human Motor Neurons, Inducing Neurodegeneration by Ferroptosis

ABSTRACT: Enterovirus 71 (EV71) causes Hand, Foot, and Mouth Disease and has been clinically associated with neurological complications. However, there is a lack of relevant models to elucidate the neuropathology of EV71 and its mechanism, as the current models mainly utilize animal model or immortalized cell lines. In this study, we established a human motor neuron model for EV71 infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261751 | GEO | 2024/08/08

REPOSITORIES: GEO