Ribosome profiling analysis of neuroblastoma cells in response to amidino-rocaglate treatment

ABSTRACT: MYCN-amplified neuroblastoma cells exhibit upregulation of translation regulation factors and ribosome biogenesis proteins as a result of MYCN-driven transcriptional amplification. Here, we treated MYCN-amplified and non-amplified neuroblastoma cells with a novel translation inhibitor, amidino-rocaglate CMLD12824, to compare the defects in translational efficiency.

ORGANISM(S): Homo sapiens

PROVIDER: GSE261760 | GEO | 2024/06/25

REPOSITORIES: GEO