Circle-seq revealing eccDNA profiling of human bone marrow mesenchymal stem cells

ABSTRACT: Extrachromosomal circular DNAs (eccDNAs) have been discovered in various species and play a significant role in cancer development However, our understanding of eccDNAs in normal cells is limited. Here, we conducted eccDNA sequencing by Circle-seq in undifferentiated human bone marrow mesenchymal stem cells (uhBMSCs) and their differentiation into osteoblasts (OBs), chondrocytes (CCs), and adipocytes (ACs) to gain knowledge about eccDNAs in cell differentiation,

ORGANISM(S): Homo sapiens

PROVIDER: GSE261856 | GEO | 2025/01/31

REPOSITORIES: GEO