RNA-sequencing of gastric cancer PDX mice model after treated with CUS

ABSTRACT: The interaction between cancer and depressive disorder remains unclear. In this study, we obtained patient data from TCGA and MDD-related (Major Depressive Disorder) genes from the GEO database and the sequencing data of the PDX model with chronic unpredictable stress (CUS). Molecular subtypes and a prognostic signature were generated based on the MDD-related genes obtained by differential expression analysis. According to our analysis, the gene signature was a promising biomarker in distinguishing the prognosis, the molecular or immune characteristics, and the depressive risk, as well as the therapy candidates for gastric adenocarcinoma patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262056 | GEO | 2024/07/19

REPOSITORIES: GEO