Transcriptomics

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HepG2 Cell : Negative control vs miR-224 vs miR1912 transfected


ABSTRACT: Microarray analysis was performed by transfection of miR-224 and miR-1912 to HepG2 cells to identify the genes regulated by miR-224 and miR-1912. miR-224 is known to down-regulate the mRNA of PCSK9, and miR-1912 was also predicted to down-regulate PCSK9 and verified in our previous experiments. PCSK9 was closely associated with the development of hyperlipidemia by interfering with the recycling of LDLR, and the decrease in PCSK9 and the increase in LDLR gene expression were greater in cells treated with miR 1912.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262184 | GEO | 2025/06/24

REPOSITORIES: GEO

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