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FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

ABSTRACT: Fatty acid binding protein 4 (FABP4) is known to play important roles in lipid metabolism in multple cell types including in macrophages. In the present study, we used single cell RNA-sequencing in macrophages extracted from either wild-type or mice deficient in FABP4 to further explore the pathways downstream of FABP4 in splenic macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE262196 | GEO | 2025/03/21

REPOSITORIES: GEO

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FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

Project description:FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

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