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Generation of synthetic kidneys from expandable kidney progenitors [Days 5 and 9]

ABSTRACT: Kidney is the central organs responsible for maintaining the homeostasis of our body, the sophisticated structure and cell composition underpin kidney’s function. Here we report the generation of mouse synthetic kidneys (SK) from expandable nephron progenitor cells (NPC) and ureteric bud (UB). Unexpectedly, versatile renal interstitial cells can be induced in synthetic kidneys. Mechanistically, a portion of NPCs go through transdifferentiation and become interstitial progenitor cells (IPCs) in SK context, then further differentiate into various renal interstitial cells. These kidney progenitors-derived synthetic kidneys highly resembled postnatal mouse kidneys in terms of high-order patterning and showed essential renal physiological functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE262462 | GEO | 2026/04/25

REPOSITORIES: GEO

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