Study of the role of circPVT1 circRNA knockdown in cardiomyocytes

ABSTRACT: circPVT1, a circRNA derived from the circularization of the second exon of the long-non coding RNA PVT1, was found upregulated in ischemic heart failure patients. We performed RNA-Seq to assess the molecular changes that occurr upon circPVT1 knockdown in AC16 cells, a human cardiomyocyte cell line. Transcriptome analysis identified differentially expressed genes mainly involved in extracellular matrix formation, fibrosis and cellular senescence, suggesting the involvement of circPVT1 in cardiac remodeling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262531 | GEO | 2025/04/29

REPOSITORIES: GEO