Melanotransferrin (MELTF, MFI2, CD228) expression attenuates malignant melanoma progression in the A375-luc2 murine metastasis model and human patients

ABSTRACT: The cell-surface glycoprotein melanotransferrin (MELTF) is a member of the iron-binding transferrin superfamily expressed in human melanocytes and other cell types. Dysregulated MELTF-expression in malignant melanoma and other malignancies has been reported before but its specific role in melanomagenesis remains elusive. We performed CRISPR/Cas9-based MELTF deletion in human A375-luc2 malignant melanoma cells followed by transcriptomic analysis in order to explore the mechanistic role of MELTF in malignant melanoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262543 | GEO | 2024/07/01

REPOSITORIES: GEO