Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic Analysis of the Candida albicans Response to Treatment with Cinnamaldehyde

ABSTRACT: Natural product cinnamaldehyde has significant antifungal activities, and its inhibitory activity against Candida albicans has been reported. Up to now, there are few reports on the changes in the transcriptome of Candida albicans after cinnamaldehyde treatment. Here, RNA sequencing analysis of samples obtained from Candida albicans cells grown in the presence or absence of cinnamaldehyde was performed. A total of 123 differentially expressed genes were identified, of which 15 genes were up-regulated and 108 genes were down-regulated.

ORGANISM(S): Candida albicans SC5314

PROVIDER: GSE262904 | GEO | 2025/06/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of intestinal epithelia of Candida albicans treated mice

Project description:Purpose: To explore the influence of Candida albicans treatment in mice intestinal epithelia. Method: 108 CFU C. albicans or PBS was gavaged to Apoe-/- mice every 3 days for 2 weeks. mRNA profiles were generated by deep sequencing.Results: Several signaling pathways were changed after C. albicans treatment, including response to hypoxia pathway.

2024-04-09 | GSE263509 | GEO

A novel compound exhibits potent anti-Candida albicans activity

Project description:Candida albicans is a prevalent fungal pathogen in humans worldwide, causing life-threatening invasive candidiasis in immunocompromised individuals, largely due to the scarcity and poor efficacy of present antifungals, necessitating the search for novel antifungal medications.By leveraging machine learning methodologies, we have identified a novel compound that demonstrates robust antifungal activity against C. albicans. To explore the mechanisms behind its efficacy, we undertook an extensive study involving transcriptomic profiling of C. albicansexposed to the compound across different cultivation times and doses.The findings of this study not only contribute to our understanding of antifungal mechanisms, but also have great potential to guide the development of innovative therapies against C. albicans for meeting the growing clinical demand for new treatments.

2025-04-01 | GSE287552 | GEO

CGH analysis of Candida albicans strains

Project description:Aneuploidy and the evolution of aneuploid karyotypes of Candida albicans strains was identified using aCGH. Whole chromosome and segmental aneuploidies, (specifically on the left arm of chromosome 5 - shown to be due to isochromosome formation) are associated with the appearance of resistance to the antifungal drug fluconazole. Keywords: Comparative Genomic Hybridization

2006-06-30 | GSE4995 | GEO

Transcriptomic Analysis of the Candida albicans Response to Treatment with Cinnamaldehyde

Project description:Transcriptomic Analysis of the Candida albicans Response to Treatment with Cinnamaldehyde

| PRJNA1094868 | ENA

Beyond the plasma membrane disruption: Novel antifungal mechanism of Neosartorya (Aspergillus) fischeri antifungal protein 2 in Candida albicans

Project description:Candida albicans is the most prevalent human pathogenic fungus, responsible for drug-resistant and fatal invasive infections which show an increasing trend in the past two decades. A promising new therapeutic approach involves NFAP2, an antifungal protein secreted by Neosartorya (Aspergillus) fischeri. NFAP2 exhibits potent antifungal activity on both planktonic and biofilm-forming Candida cells in vitro and in vivo. Despite this promising feature,the exact antifungal mechanism of NFAP2 remains in the shadow which hampers its therapeutic application. Based on our recent observations, we suppose that NFAP2 is taken up by Candida cells, and has a long-term growth-slowing effect. Our objective was to understand the molecular mechanism of the long-term growth slowing effect of NFAP2 in C. albicans, therefore the transcriptome of the NFAP2-treated (below the minimum inhibitory concentration) C. albicans SC5314 cultures was compared to that of the untreated ones.The transcriptional responses to NFAP2 were further characterized using functional enrichment analyses of Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways.

2025-03-03 | GSE290357 | GEO

Antifungal Activity of Mammalian Serum amyloid A1 against Candida albicans

Project description:Human serum amyloid A (SAA) is a major acute phase protein and shows a massive increase of concentration in plasma during inflammation. In the current study, we report that recombinant human and mouse SAA1 (rhSAA1 and rmSAA1) have a potent antifungal activity against the major fungal pathogen Candida albicans. rhSAA1 binds to the cell surface of C. albicans and promotes cell aggregation. At high concentrations, rhSAA1 disrupts the membrane integrity and induces rapid cell death of C. albicans. Further investigation demonstrates that rhSAA1 targets on the cell wall adhesin Als3 of C. albicans. Inactivation of ALS3 in C. albicans leads to remarkably decreased cell aggregation and death upon rhSAA1 treatment, implying that Als3 plays a critical role in SAA1 sensing. Moreover, deletion of the ALS3 transcriptional regulators such as AHR1, BCR1, and EFG1 in C. albicans results in a similar effect on cell responses to that of the als3/als3 mutant upon rhSAA1 treatment. Global gene expression profiling analysis indicates that rhSAA1 has a remarkable impact on the expression of cell wall- and metabolism-related genes in C. albicans. Our finding of the antifungal activity of rhSAA1 against C. albicans expands the function of this protein and would provide new insights into the understanding of the host-Candida interaction during infections.

2019-09-01 | GSE128598 | GEO

Candida albicans

Project description:Response of Candida albicans towards a novel antifungal benzimidazole derivative

| PRJNA127111 | ENA

Microarray experiment of Candida albicans treated with synthetic peptides

Project description:To investigate the mode of action of a novel class of antifungal synthtic acrylamide peptides, the pathogenic yeast, Candida albicans, was exposed to sublethal doses of peptides with different structures. The experiments include the most effective structure, LH, peptides with no antifungal effects (HEAm) and intermediates as well as controls.

2024-06-18 | E-MTAB-13294 | biostudies-arrayexpress

Candida albicans exposure to antifungal polymers

Project description:Candida albicans exposure to antifungal polymers

| PRJEB65085 | ENA

Candida albicans

Project description:UPC2 Is universally essential for Azole antifungal resistance in Candida albicans

| PRJNA248441 | ENA