Hyperoxia impairs iPSC derived endothelial cells and drives an atherosclerosis-like transcriptional phenotype

ABSTRACT: Induced pluripotent stem cells (iPSCs) directed to endothelial identity (iPSC-ECs) lose expression of key identity markers under standard in vitro conditions, limiting their clinical applications. We examined iPSC-ECs at late passage (>2 weeks) under hyperoxic (21%)conditions with single cell RNA sequencing

ORGANISM(S): Homo sapiens

PROVIDER: GSE263090 | GEO | 2024/04/05

REPOSITORIES: GEO