Neuronal CD47 Induces Microglial Phagocytosis Defects and Autism-like Behaviors While Mitigating Aβ-Induced Synaptic Loss
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ABSTRACT: Neuronal CD47 is a potent "do not eat me" signal that protects synapses from excessive pruning by microglia. We used an adeno-associated viruses gene expression system to induce neuron-specific CD47 overexpression in wild-type and 5xFAD mice,and we used single nucleus RNA sequencing (snRNA-seq) to analyze the diversity of neurons and microglia in the hippocampus.
ORGANISM(S): Mus musculus
PROVIDER: GSE263398 | GEO | 2025/09/01
REPOSITORIES: GEO
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