Identification of genes regulated by knockdown of EWS-FLI1 in Ewing sarcoma cells.

ABSTRACT: EWS-FLI1 is the driver oncogene in >85% of Ewing sarcoma tumors. We used siRNA to knock down EWS-FLI1 for 48h hours in two Ewing sarcoma cell lines (EW8, TC71) to identify downstream genes and pathways affected by loss of EWS-FLI1 activity. RNAseq analysis was performed after 48 hours of treatment with a nontargeting siControl or siEWS-FLI1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE263504 | GEO | 2024/09/30

REPOSITORIES: GEO