Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids.

ABSTRACT: Kidney organoids derived from human iPSCs have cell heterogeneity of maturation. We used single-cell RNA sequencing (scRNAs-seq) to extract the factor related to proximal tubule maturation. Using the kidney organoids cultured with the factors that accelerate the maturation speed of proximal tubules extracted by the aforementioned method, we examined whether the maturity of the proximal tubules increases within the same induction period.

ORGANISM(S): Homo sapiens

PROVIDER: GSE263556 | GEO | 2024/10/11

REPOSITORIES: GEO