Transcriptomics

Dataset Information

18

S100A8/A9 activate key genes and pathways in colon tumor progression


ABSTRACT: Studies using bone marrow chimeric mice revealed that S100A8/A9 expression on myeloid cells is essential for development of colon tumors. Our results thus reveal a novel role for myeloid-derived S100A8/A9 in activating specific downstream genes associated with tumorigenesis and in promoting tumor growth and metastasis. Overall design: Subconfluent cultures of MC38 cells were serum-starved for 16 hrs and activated with 10ug/mL S100A8/A9 for 6 hrs. Total RNA was extracted from unactivated or activated cells. 2 replicates each per stimulated cells, unstimulated cells, and control cells.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

ORGANISM(S): Mus musculus  

SUBMITTER: Roy M Williams   

PROVIDER: GSE26359 | GEO | 2011-02-01

SECONDARY ACCESSION(S): PRJNA135039

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2014-05-13 | E-GEOD-26359 | ArrayExpress
2015-01-13 | E-GEOD-62282 | ArrayExpress
2014-09-07 | E-GEOD-60748 | ArrayExpress
| GSE122552 | GEO
2014-10-31 | E-GEOD-62793 | ArrayExpress
| PRJNA126921 | ENA
| PRJNA264851 | ENA
| PRJNA135039 | ENA
| PRJNA106001 | ENA
2014-06-03 | E-GEOD-56783 | ArrayExpress