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Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE26379 | GEO | 2012/02/02

SECONDARY ACCESSION(S): PRJNA136607

REPOSITORIES: GEO

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Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation

Project description:This SuperSeries is composed of the following subset Series: GSE26376: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA) GSE26377: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression) Refer to individual Series

2012-02-02 | E-GEOD-26379 | biostudies-arrayexpress

Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA)

2012-02-02 | GSE26376 | GEO

Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA)

Project description:Since the expression profile of miRNAs is specific in different tissues or under different physiological conditions, the correlations between miRNAs and mRNAs could vary under different biological circumstances. This is a study also used expression profiles of miRNA and mRNA during monocytic differentiation to explore the correlations between the expression levels of miRNAs and mRNA, either negative or positive. After treatment of TPA, U937 cells present functional differentiation markers as well as specific cell morphology, which were confirmed by flow cytometric analysis and Wright-Giemsa staining.Here we use a miRNA microarray (CapitalBio, Beijing, China) containing 509 well-characterized human, mouse and rat miRNAs and various controls to profile the expression levels of miRNA in normal U937 cells and differentiated U937 cells. Three independent biological experiments were performed, and for each differentiated and control sample, two hybridizations were performed by using a reversal fluorescent strategy.

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Project description:Since the expression profile of miRNAs is specific in different tissues or under different physiological conditions, the correlations between miRNAs and mRNAs could vary under different biological circumstances. This is a study also used expression profiles of miRNA and mRNA during monocytic differentiation to explore the correlations between the expression levels of miRNAs and mRNA, either negative or positive. After treatment of TPA, U937 cells present functional differentiation markers as well as specific cell morphology, which were confirmed by flow cytometric analysis and Wright-Giemsa staining.Here we use genome-wide microarray analysis to profile the expression levels of mRNA in normal U937 cells and differentiated U937 cells. For each differentiated and control sample, two hybridizations were performed by using a reversal fluorescent strategy.

2012-02-02 | E-GEOD-26377 | biostudies-arrayexpress