Integrated transcriptomic, epigenetic, and TCR clonality analysis of CD4⁺ Tm subsets in liver and lung during chronic GVHD in mice [scTCR-seq]

ABSTRACT: Pathogenic CD4+ T cells perpetuate chronic tissue inflammation, but mechanisms remain largely undefined. Here, with transcriptome, epigenome, and clonal analysis, we compared CD4+Tm subsets among the liver and lung in the No GVHD and cGVHD recipients. Four CD4+Tm subsets identified with Ly108 versus CD69 expression were compared

ORGANISM(S): Mus musculus

PROVIDER: GSE263813 | GEO | 2025/12/11

REPOSITORIES: GEO