Genetic disruption of class I HLA in cutaneous T-cell lymphoma

ABSTRACT: Genetic disruption of class I HLA is a common mechanism of immune evasion and immunotherapy resistance in many other cancers but has not yet been characterized in cutaneous T-cell lymphoma (CTCL). We performed single-cell RNA sequencing (scRNA-seq) on tumor samples from patients with CTCL to demonstrate the tumor-specificity and intratumoral heterogeneity of such abnormalities.

ORGANISM(S): Homo sapiens

PROVIDER: GSE263881 | GEO | 2025/02/05

REPOSITORIES: GEO