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Notch signaling in CD66+ cells drives the progression of human cervical cancers

ABSTRACT: Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the Lin-CD66+ and the Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation. This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE26419 | GEO | 2011/06/09

SECONDARY ACCESSION(S): PRJNA136795

REPOSITORIES: GEO

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Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

Project description:Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the cancer stem cell-like Lin-CD66+ and the bulk Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation.

2011-06-09 | GSE26418 | GEO

Microarray analysis of CaSki cell line grown as spheroids and adherent conditions

2011-06-09 | GSE26417 | GEO

Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

2011-06-09 | E-GEOD-26418 | biostudies-arrayexpress

Notch signaling in CD66+ cells drives the progression of human cervical cancers

Project description:Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the Lin-CD66+ and the Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation. Refer to individual Series. This SuperSeries is composed of the following subset Series: GSE26417: Microarray analysis of CaSki cell line grown as spheroids and adherent conditions GSE26418: Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

2011-06-09 | E-GEOD-26419 | biostudies-arrayexpress

Microarray analysis of CaSki cell line grown as spheroids and adherent conditions

2011-06-09 | E-GEOD-26417 | biostudies-arrayexpress

Homo sapiens

Project description:Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

| PRJNA142253 | ENA

Transcription profiling of human prostate cancer cell line to determine Ebp1 effect in prostate cancer

Project description:Therapies targeting the androgen receptor are critical for treatment of hormone refractory prostate cancer. We have previously demonstrated that Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased in preclinical models of hormone refractory prostate cancer, we studied the ability of Ebp1 to mitigate the hormone refractory phenotype. As we previously found that Ebp1 affected the expression of some androgen receptor target genes, we sought to determine a full spectrum of genes changed using an unbiased appraoch by microarry analysis. Experiment Overall Design: A hormone independent cell line C81 was derived from LNCaP cells by long term passage and was a kind gift of Dr. Lin (University of Nebraska). C81 cell were transfected with a vector control or EBP1 expression plasmids and mass cultures selected. RNA was collected from logaritmically growing cultures.

2008-11-13 | E-GEOD-12200 | biostudies-arrayexpress

Gene epxression profiling in murine bone marrow Lin- cells transduced with BCR-ABL and/or IRF8 followed by Flt3L culture for 5 days

Project description:To understand the effect of BCR-ABL and IRF8 on gene expression pattern during in vitro dendritic cell differentiation, microarry analysis was performed. Murine bone marrow Lin- cells were transduced with retroviruses carrying human BCR-ABL cDNA and/or mouse Irf8 cDNA, and then cultured with Flt3L for 5 days. Two independent experiments were performed.

2013-11-15 | E-GEOD-44920 | biostudies-arrayexpress

Identification of target genes regulated by NANOG-HDAC1 axis

Project description:To gain insight into the role of HDAC1 in NANOG-mediated transcriptional regulation, we performed genome-wide RNA-sequencing analysis (RNA-seq) in CaSki-no insert-siGFP, CaSki-NANOG-siGFP and CaSki-NANOG-siHDAC1 cells.

2018-10-18 | GSE88965 | GEO

CaSki cells: adherent cultured cell vs. sphere cells

Project description:Transcriptional profiling of human cervical squamous cell carcinoma cell line CaSki comparing adherent cultured cells with spheres cultured in serum free culture medium. Goal was to identify candidate antigens for immunotherapy targeting cancer stem cells. Two-condition experiment, CaSki vs. CaSki-sphere cells.

2015-03-04 | E-GEOD-65499 | biostudies-arrayexpress

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