Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth

ABSTRACT: Medulloblastoma metastasis often occurs in the leptomeningeal spaces; however, the biology of the metastatic tumour cells and the local leptomeningeal niche are poorly characterized. We performed single-cell RNA sequencing to analyze the leptomeningeal metastatic niche in a medulloblastoma mouse model.

ORGANISM(S): Mus musculus

PROVIDER: GSE264326 | GEO | 2025/03/14

REPOSITORIES: GEO