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Gene expression data of PBMC and hippocampus of young rats with metabolically obese, normal-weight phenotype and normal-weight controls

ABSTRACT: The metabolically obese, normal-weight (MONW) phenotype is characterized by visceral adiposity and obesity-related complications like insulin resistance or even cognitive impariment, despite a lack of excess body weight. Thus, early identification of individuals with this phenotype is crucial for implementing effective preventive strategies. Peripheral blood mononuclear cells (PBMC) serve as valuable source of biomarkers in obesity research since they can be collected with minimun invasiveness and are able to reflect gene expression alterations in internal organs, such as the liver or brain. This study aims to analyze alterations in gene expression profile in PBMC and the hippocampus of young rats with MONW phenotype induced by the intake of a high-fat diet, compared to normal-weight controls. Altered transcriptomic profiles in these biological samples can help to identify early biomarkers of metabolic damage related to the MONW phenotype. Furthermore, we aim to investigate the potential therapeutic effects of perinatal treatment with the anti-obesity hormone leptin on metabolic health in MONW animals.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE264559 | GEO | 2025/12/09

REPOSITORIES: GEO

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