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Neighboring genomic regions influence differential methylation patterns of CpG islands in endometrial and breast cancers

ABSTRACT: We report the global methylation patterns by MBDCap-seq for total 232 primary samples in endometrial cohorts, breast cancer cohorts and breast cancer cell lines. We found total 1,007 differentially methylated regions (DMRs) include CpG islands and shores in endometrial cohorts, and 2529 for Breast Cancer cohorts. We also identified 153 regions that are distinctly different from regular CpG islands at the 5'-ends of genes. Those regions, always contain a chain of 1-2 main islands and a few satellites alone on GC-poor and gene-less region. Majority of CpG atolls contain lowly transcribed or silenced genes in normal controls. This phenomenon provides a new opportunity to develop sensitive biomarkers for cancer diagnosis and prognosis

ORGANISM(S): Homo sapiens

PROVIDER: GSE26592 | GEO | 2012/01/11

SECONDARY ACCESSION(S): PRJNA136187

REPOSITORIES: GEO

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Methylation detection Oligonucleotide Microarray Analysis: high resolution method for CpG island methylation detection 1

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2009-04-28 | E-GEOD-15746 | biostudies-arrayexpress

Homo sapiens

Project description:Neighboring genomic regions influence differential methylation patterns of CpG islands in endometrial and breast cancers

| PRJNA136187 | ENA

Methylation detection Oligonucleotide Microarray Analysis: high resolution method for CpG island methylation detection 2

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