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Mucin O-glycans protect host cells by tempering pneumolysin expression in Streptococcus pneumoniae

ABSTRACT: The ability of mucosal epithelia to sustain asymptomatic colonization by pathogens, such as Streptococcus pneumoniae (Spn), remains a significant and unresolved scientific question. This study reveals that mucins—the main gel-forming elements of mucus—and their associated glycans, suppress the expression of pneumolysin, a Spn toxin that causes tissue injury and triggers inflammatory responses. These findings highlight a unique protective function of mucins, offering insights into potential therapeutic strategies.

ORGANISM(S): Streptococcus pneumoniae TIGR4

PROVIDER: GSE265984 | GEO | 2025/04/26

REPOSITORIES: GEO

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